Search Site
Professor Muhammad Asim Khan
Text Only Vervsion
Home Page About Us Contact Us Donations and sponsorship
Home Page Ankylosing Spondylitis Research
image image
image This site summarizes the latest research in AS
This site summarizes the latest research in AS
Ankylosing spondylitis - the facts
A little history
Ankylosing spondylitis and its family (The Spondyloarthropathies)
Fatigue
Flares
Bones & AS
Pregnancy and ankylosing spondylitis
RELATED CONDITIONS  - Iritis - Psoriasis - Inflammatory bowel disease - Rare complications
PAIN MANAGEMENT - Introduction to pain - Self  management of pain
Medication - Anti-inflammatories, Sulfasalazine, Methotrexate, Anti-TNF
Alternative Medicines
Genetics
Expert opinion  Prof. M Khan: diagnosis
Frequently asked questions
image



Professor Muhammad Asim Khan
The author has had AS for the past
46 years. He is Professor in the
University School of Medicine , Division of Rheumatology , Cleveland, Ohio.

Symptom onset to diagnosis: a bridge too far

Only a doctor fully aware of the nature of AS would consider the possibility of AS when presented with a young person with chronic back pain. Yet, this is the typical presentation of AS. Unfortunately, the presence of back pain during the 'pre-spondylitis' phase, which can last 5-10 years or longer, is accompanied by progressive structural damage that may take place inconspicuously. Diagnosis is often established when AS reaches the stage where structural damage has led to easily recognizable abnormal physical findings or X ray abnormalities, or both. A study conducted by the German AS society in 1996 found that the average age at onset of AS symptoms was 25.7 years and the average delay in diagnosis was 8.9 years. A significantly greater delay in diagnosis was seen among women than among men. This discrepancy in disease detection among men and women reflects the common problem of under diagnosis of AS among women, probably owing to the misconception that women rarely have AS.

 


This misconception may result from slower progression of the typical spinal changes in women. Many investigators have tried to set and refine guidelines for the diagnosis of AS. However, current diagnostic criteria mean that a definite diagnosis of AS cannot be made unless the person shows unequivocal radiological evidence of X ray change in the pelvis. This criteria does not acknowledge juvenile patients or those in their late teens or early twenties with disease activity that has not progressed to the point where the changes in their pelvis is unequivocally detected by the X ray. Thus, the diagnosis and treatment of AS in the early stages may often be related more to the persons clinical presentation and to the doctors personal experience and intuition than precise diagnostic criteria.

Vert[Top of page]

Early diagnosis of AS is highly desirable because it enables the treatment to start before permanent damage has occurred. However, a global consensus needs to be reached on criteria for diagnosis and classification for AS that reflects the broad range of symptoms and spinal changes.

At present a wide assortment of methods for assessing AS have been suggested but no particular method has been accepted universally and no guidelines for the use of assessment measures have been established. 

However, a workshop (ie the Ankylosing spondylitis Workshop Berlin, Germany Jan 2002) on the new treatment strategies was a timely event that profiles a solid foundation to enable dramatic improvement in the management of people with AS in the near future. For the first time there is a real possibility of controlling and modifying the course of AS.

This summary is an edited version of Prof. Khan's article ' Ankylosing spondylitis : introductory comments on its diagnosis and treatment' Ann Rheum Dis 2002 SIII: iii3-iii5

[Top of page]


[
Email]Vert[Email]

This site is sponsored by : NASS(National Ankylosing Spondylitis Society) | Web Hosting sponsored by Ark Computer Consultancy Ltd