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Ankylosing Spondylitis Research

This site summarizes the latest research in AS

This site is
sponsored by :


NASS
(National Ankylosing
Spondylitis Society)
 
 
 
 

Psoriasis

What is Psoriasis?

The name psoriasis comes from the Greek word psora, referring to itchiness.

It is a skin condition where the immune system causes inflammation in the skin. It is NOT catching. It comes in different forms and varying levels of severity and affects about 2% of white people (this figure is lower for African, Latin American Indians and Oriental people).

Psoriasis is usually a mild condition, about 75% of people have mild disease and about 25% have moderate to severe psoriasis. Generally, mild disease may affect only a small portion of the body i.e. the knees, elbows, scalp, hands or feet. Creams, shampoos and moisturizers are usually enough to keep the psoriasis at bay. Severe and moderate psoriasis will cover more of the body and may cause severe peeling of the skin and may need treatment with drugs or light therapy (ie UV lamp). In some cases psoriasis can also affect the nails and cause pits. It can appear like an area of weeping skin with scaling, intense inflammation with little scaling, or intense peeling of the skin with a lot of inflammation.

People with psoriasis may develop arthritis , people with arthritis symptoms may develop psoriasis. In fact, 3 people in every 20 with AS will also have psoriasis. This could be psoriatic arthritis or AS and psoriasis. Telling the difference between these two is difficult and requires a specialist and often tests. A person with psoriatic arthritis may have arthritis in one area, in the fingers, only on one side of the body or they may have spinal and pelvic involvement as is seen in AS. 

 

Generally, a person with psoriatic arthritis has

1. more neck arthritis, 

2. the inflammation may be more on one side of the body than the other.

3. the bony growths coming from the vertebrae in the spine may be more large and course. 

A person with AS and psoriasis has :

1. more spinal arthritis 

2. inflammation symmetrically (ie on both sides of the pelvis and on both sides of the body)

3. finer bony growths on the vertebrae.. 

Psoriasis does NOT scar the skin and is characterized by clearing up with treatment and then re-appearing again. 

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What causes psoriasis ?:

The development of psoriasis depends on very complex genetic and environmental interactions ie this disorder runs in families and has been linked to triggering infections (ie throat infection) as well as trauma to the skin and reactions to some drugs. Some of the genes involved in causing psoriasis may be the same genes, or very close to the genes that cause AS. 

The severity of the psoriasis is also dependent on genetic and environmental (ie stress, smoking, alcohol) factors. Fluctuations in the immune system (ie the chemicals used to defend the body) are strongly linked to the severity of psoriasis. This is why behavioral therapy to deal with stress and trauma can be a great help in treating psoriasis.

In psoriasis the immune system is triggered which speeds up the growth of skin cells. A normal skin cell is shed every 28-30 days (monthly) but a psoriatic skin cell matures and moves to the skin surface to be shed every 3-4 days. So, skin piles up and can not be shed fast enough and forms red lesions.

Psoriasis can occur at any age and can occur before or after the onset of arthritis symptoms.

Certain genes such as B27 and others are associated with more progression. A high level of inflammation early on (ie very bad psoriasis early on) is a predictor of progression in the future. High levels of some immune chemicals (ie IgA) predict a more severe outcome.

What can I do about psoriasis ?

For severe psoriasis, there are many drugs that your doctor may prescribe that are very good at controlling this condition such as methotrexate, sulphasalazine or CyclosporinA and the new drug anti-TNF has been shown to be very effective in trials at treating psoriasis.

Stress reduction, not smoking or drinking heavy can help in not aggravating this condition. 

Alcohol can make psoriasis worse and reduce the effects of treatment. Natural sunshine can be beneficial but some people report that it can make their psoriasis worse. 

Sites that may help :

Books - Psoriasis at your Fingertips Dr Tim Mitchell & Rebecca Penzer.

Skin care for psoriasis. Dr V K Dave

Organizations - 

The Psoriasis Association, 
7 Milton Street, 
Northampton.
NN2 7JG. 
Telephone : 01604 711129

Psoriatic Anthropathy Alliance,
136 High Street,
Bushey ,
Herts
WD2 3DJ 
Telephone : 01923 67837

Web sites

www.paaliance.org

                      www.dermatology.co.uk

                      www.psoriasis.org

                      www.psoriasissupport.com

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